The accident happened around 8:30 p.m., when a maroon 1991 Plymouth Sundance attempted to turn left off of KY 72 onto U.S. 119 into the path of an oncoming red 1994 Jeep Cherokee heading north.
The Jeep swerved, then struck the Plymouth in the driver's side of the vehicle, according to police.
Both the driver of the Plymouth, Robert D. Frazier, Middlesboro, and passenger, Judy Hobbs Baker, Blackmont, were pronounced dead at the scene by Bell County Coroner Clyde Creech.
Frazier was 24 and Baker was 35.
Police are still investigating whether drugs or alcohol contributed to the accident.
The driver of the Jeep, Charles Worthington, of Evarts, walked away from the wreck.
But a passenger in the Jeep, Donna Worthington, also of Evarts, was hurt. She was flown by helicopter to the University of Tennessee Medical Center with serious injuries.
Both vehicles sustained severe damage.
KSP Trooper Jimmy Young II and collision reconstructionist Sgt. P.J. Burnett investigated the accident. They were assisted by Sgt. Micky Hatmaker and Trooper Keith Baker.
Bell County Sheriff's Department responded to the accident at 8:27 p.m., then called the Kentucky State Police for assistance.
Bell County Emergency Rescue Squad and the Bell County Volunteer Fire Department also assisted.